Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil.

نویسندگان

  • Sofie P M Janssen
  • Marko Phernambucq
  • Pilar Martinez-Martinez
  • Marc H De Baets
  • Mario Losen
چکیده

Currently used non-specific immunosuppressive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (AChRs) and subsequently treated with MMF or vehicle. MMF treatment resulted in a significant suppression of anti-rat AChR antibody titers. Interestingly, no abnormalities of neuromuscular transmission and adverse side effects were detected in MMF-treated EAMG animals. Moreover, anti-rat AChR antibody titers correlated to an improvement of clinical outcome. In conclusion, our data suggest that MMF acts as a potent immunosuppressant drug in EAMG.

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عنوان ژورنال:
  • Journal of neuroimmunology

دوره 201-202  شماره 

صفحات  -

تاریخ انتشار 2008